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MTX and HDMTX uses

MTX

  • Cytotoxic agent used for treatment of malignancies since the 1950s1
  • Interferes with DNA synthesis in cancer cells, which is necessary for cancer cell growth and survival2

HDMTX

  • Commonly used to treat several adult and paediatric cancers2,3-6


Burkitt lymphoma
Primary central nervous
system (CNS) lymphoma
Diffuse large B-cell
lymphoma
Adult acute lymphoblastic
leukaemia (ALL)
Paediatric ALL
Osteosarcoma


Abbreviations: ALL, acute lymphoblastic leukaemia; CNS, central nervous system; HDMTX, high dose methotrexate; MTX, methotrexate.