Steer
with
Guidance
Helping physicians navigate
HDMTX* treatment pathways
FOR THE MANAGEMENT OF [HIGH DOSE] MTX TOXICITY
AUTHORISED UNDER EXCEPTIONAL CIRCUMSTANCES
Delayed methotrexate (MTX) elimination can be an oncologic emergency
High-Dose Methotrexate (HDMTX) Toxicity and Acute Kidney Injury
Keep Voraxaze top-of-mind when treating with HDMTX
Learn about HDMXT Toxicity
Identify and TreatDelayed MTX Clearance Early
Consensus Guidelines recommend early use of Voraxaze.2
View GuidelinesLatest Updates
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Anish Tailor video
Watch Anish Tailor, Lead Haematology Pharmacist from UCLH, discuss his approach to managing delayed MTX elimination with glucarpidase in adult patients with lymphoma.
UK-VRX-2500020 Date of Last Revision: February 2026
WATCH NOW
Vanessa McLelland
Watch Vanessa McLelland, Lead Paediatric Pharmacist from UHBW, present her approach on managing delayed MTX elimination with glucarpidase in paediatric patients.
UK-VRX-2500022 Date of Last Revision: February 2026
WATCH NOW
Raakhee Shah video
Watch Raakhee Shah, Lead Haematology Pharmacist from UCLH, present her thoughts on the prevention, management, and challenges with HDMTX-induced nephrotoxicity.
UK-VRX-2500021 Date of Last Revision: February 2026
WATCH NOWReferences
- Summary of Product Characteristics (SmPC), Voraxaze®.
- Ramsey LB, et al. Consensus guideline for use of glucarpidase in patients with high-dose methotrexate induced acute kidney injury and delayed methotrexate clearance. Oncologist. 2018;23(1):52-61.
HOW TO ORDER VORAXAZE:
Order Voraxaze via Oxford Pharmacy Store (OPS)
9am-5pm Mon – Fri (Exc. Bank Holidays)
Call: 01865 904141 or email: ops.orders@oxfordhealth.nhs.uk Item Code: VOR002
OUT OF HOURS ORDERS (ONLY BETWEEN 5pm-10pm Mon – Fri, 9am-5pm Sat/Sun/BH):
Call Warneford Hospital switchboard on: 01865 901000 & ask to speak to the Oxford Pharmacy Store (OPS) on-call team.
PLEASE NOTE: OPS will aim to dispatch within 24 hours.
UK-VRX-2600030 Date of Last Revision: February 2026
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