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Voraxaze works in the circulation

Voraxaze® Works in the Circulation to Quickly Clear Methotrexate (MTX)1,4

Voraxaze and Leucovorin Work Differently1,2

  • Voraxaze® (glucarpidase) lowers toxic levels in the extracellular compartment, whereas leucovorin counteracts MTX intracellularly. Only Voraxaze rapidly reduces plasma MTX concentrations by hydrolyzing extracellular MTX
  • Voraxaze rapidly cleaves MTX into 2 inactive metabolites to provide a nonrenal pathway for elimination. 1,3

VORAXAZE® converts MTX to INACTIVE METABOLITES within 15 minutes1,4

Abbreviations: DAMPA, 4-deoxy-4-amino-N10-methylpteroic acid; MTX, methotrexate.