Resources

UK-VRX-2500020 Date of Last Revision: February 2026

Anish Tailor video

Watch Anish Tailor, Lead Haematology Pharmacist from UCLH, discuss his approach to managing delayed MTX elimination with glucarpidase in adult patients with lymphoma.

UK-VRX-2500022 Date of Last Revision: February 2026

Raakhee Shah video

Watch Raakhee Shah, Lead Haematology Pharmacist from UCLH, present her thoughts on the prevention, management, and challenges with HDMTX-induced nephrotoxicity.

UK-VRX-2500021 Date of Last Revision: February 2026

Vanessa McLelland

Watch Vanessa McLelland, Lead Paediatric Pharmacist from UHBW, present her approach on managing delayed MTX elimination with glucarpidase in paediatric patients.

Royal College of Emergency

Royal College of Emergency Medicine and National Poisons Information Service Guideline on Antidote Availability for Emergency Departments¹
(Version 6, December 2022)

• These drugs are held in specialist sites for supply in England.
• Glucarpidase for methotrexate toxicity is held at Oxford Pharmacy Stores.

Clinical Commissioning Policy

Clinical Commissioning Policy: Glucarpidase for the urgent treatment of methotrexate induced renal dysfunction²

• NHS England will commission Glucarpidase for the urgent treatment of methotrexate-induced renal dysfunction in accordance with the criteria outlined in this document.

Journal of Cancer research and clinical oncology

A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment
(Published October 2024)

• Early recognition of DME is important to promptly implement appropriate treatment including, intensified hydration, high-dose leucovorin and, when appropriate, glucarpidase.