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UK-VRX-2600029 Date of Last Revision: February 2026

Steer
with
Guidance

 Helping physicians navigate
HDMTX* treatment pathways 

FOR THE MANAGEMENT OF [HIGH DOSE] MTX TOXICITY
AUTHORISED UNDER EXCEPTIONAL CIRCUMSTANCES

Voraxaze® is indicated to reduce toxic plasma methotrexate concentration in adults and children (aged 28 days and older) with delayed methotrexate elimination.
Delayed methotrexate (MTX) elimination can be an oncologic emergency
Group 15

Why Stock Voraxaze

Voraxaze lowers plasma MTX by >98% in 15 minutes.1

View Efficacy
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High-Dose Methotrexate (HDMTX) Toxicity and Acute Kidney Injury

Keep Voraxaze top-of-mind when treating with HDMTX

Learn about HDMXT Toxicity
Group 16

Identify and TreatDelayed MTX Clearance Early

Consensus Guidelines recommend early use of Voraxaze.2

View Guidelines

Latest Updates

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image 20

Anish Tailor video

Watch Anish Tailor, Lead Haematology Pharmacist from UCLH, discuss his approach to managing delayed MTX elimination with glucarpidase in adult patients with lymphoma.

UK-VRX-2500020 Date of Last Revision: February 2026

WATCH NOW
image 20

Vanessa McLelland

Watch Vanessa McLelland, Lead Paediatric Pharmacist from UHBW, present her approach on managing delayed MTX elimination with glucarpidase in paediatric patients.

UK-VRX-2500022 Date of Last Revision: February 2026

WATCH NOW
image 20

Raakhee Shah video

Watch Raakhee Shah, Lead Haematology Pharmacist from UCLH, present her thoughts on the prevention, management, and challenges with HDMTX-induced nephrotoxicity.

UK-VRX-2500021 Date of Last Revision: February 2026

WATCH NOW

References

  1. Summary of Product Characteristics (SmPC), Voraxaze®.
  2. Ramsey LB, et al. Consensus guideline for use of glucarpidase in patients with high-dose methotrexate induced acute kidney injury and delayed methotrexate clearance. Oncologist. 2018;23(1):52-61.

HOW TO ORDER VORAXAZE:

Order Voraxaze via Oxford Pharmacy Store (OPS)

 

9am-5pm Mon – Fri (Exc. Bank Holidays)

Call: 01865 904141 or email: ops.orders@oxfordhealth.nhs.uk Item Code: VOR002

OUT OF HOURS ORDERS (ONLY BETWEEN 5pm-10pm Mon – Fri, 9am-5pm Sat/Sun/BH):

Call Warneford Hospital switchboard on: 01865 901000 & ask to speak to the Oxford Pharmacy Store (OPS) on-call team.

PLEASE NOTE: OPS will aim to dispatch within 24 hours.

UK-VRX-2600030 Date of Last Revision: February 2026